NextGen Accelerator Grants
At the Cell Discovery Network, our mission is to create and nurture a vibrant community of scientists at BCH who are actively using single-cell technologies in their research. Through the next phase of our Accelerator Grant Program, we are dedicated to empowering researchers already working with single-cell approaches by providing the resources and support needed to push the boundaries of their work.
For example, going from inferred cell clusters and interactions to tissue-scale mechanisms would greatly benefit from faithful model systems, spatial registration, or perturbation experiments. Our first round of Accelerator grants will aim to promote innovative projects bridging the gap between single-cell genomics and the clinical setting.
Some areas of emphasis include, but are not limited to, projects aiming to:
- Enable novel computational tool development
- Link single cell data across or with other modalities
- Use single cell in a clinical setting to improve treatment and diagnostics
For us, building a community means having fellow scientists with whom to learn and discuss all things single-cell!
The CDN will provide structured learning opportunities to awardees as well as to the wider research community at BCH. By designing workshops and courses on current overarching problems in the single-cell space we aim to create the space to nurture and grow this community.
Accelerator Grant Awardees 2024
- Spatially Resolved Clonal Analysis of Neonatal Heart Regeneration – Miao Cui
- Discovering the immunogenetic basis of pediatric nephrotic syndrome through single-cell omics – Matthew Sampson
- Generating a Cross-species Choroid Plexus Atlas – Maria K. Lehtinen
- Single-cell Profiling of Gut Tissue and Peripheral Blood in FPIES – Elena Crestani
- Immunologic Determinants of Autoimmune Cytopenias – Janet Chou
Next Gen Accelerator Grant Awardees 2025
- Full-Length Transcriptomics of FMRP-Deficient Neurons: Insights into Human Fragile X Syndrome – Aditi Singh
- A cell atlas of Batten pathobiology & therapeutic response – Aikaterini Chatzipli
- A systematic multi-organ profiling of cell clonality and identity in intra-uterine growth restriction (IUGR) – Alexandra Maria Bisia
- Investigation of Single-Cell Molecular Profiles of Thymic Epithelial Cells Across Developmental Stages – Deeptarup Biswas
- Epitope Edited Stem Cells to Enable Next-Generation Non-Genotoxic Transplantation Protocols– Gabriele Casirati
- Connecting chromatin organization to alterations in gene regulation and neural cell fate in autism – Max Horlbeck
- Unraveling Genetic and Epigenetic Interplay in Microglia during Alzheimer’s Disease Using Nanopore Single-cell Whole-genome Sequencing Technology – Mengyue Zheng
- AI-guided synthetic intron design for gene therapy using single-cell long-read sequencing – Mingyun Bae
- Live-cell single cell transcriptomics – Mohamad Najia
- Computational Models for Tissue Niche Regulation in Left Ventricular Noncompaction Disease – Rongbin Zheng
- Gene-Gene Estimated Correlation – Seung Han Baek
- A multiomic approach to map transcription factor binding in early neural development – Shirley Liau
- Investigating mechanisms underlying Transcription Factor dosage sensitivity in the developing Enteric Nervous System – Sunil Guharajan
- Dissecting spatial-temporal regulatory networks in endocardial fibroelastosis with single-cell spatial transcriptomics – Yang Yu
- Mapping of Macrophage-Fibroblast Interactions by Integrating Chemical Labeling and Single-Cell CRISPR Perturb-Seq – Yu Hong